还原型谷胱甘肽联合熊去氧胆酸治疗非酒精性脂肪肝的临床效果(1)
【摘要】 目的：探討还原性谷胱甘肽联合熊去氧胆酸治疗非酒精性脂肪肝的临床效果。方法：选取笔者所在医院2015年1月-2018年10月收治的120例非酒精性脂肪肝患者，采用随机数字表法将其分为联合组和对照组，各60例。对照组采用还原型谷胱甘肽治疗，联合组在此基础上加用熊去氧胆酸治疗，对比两组患者治疗前后肝功能、血脂指标、肝脾CT比值、炎症指标的变化。结果：治疗前，两组血清ALT、AST、TBIL、ALP、GGT水平比较，差异无统计学意义(P>0.05);治疗后，联合组血清ALT、AST、TBIL、ALP、GGT水平均显著低于对照组，差异有统计学意义(P<0.05)。治疗前，两组血清TC、TG、HDL-C、LDL-C水平比较，差异无统计学意义(P>0.05);治疗后，联合组血清TC、TG、LDL-C水平均显著低于对照组，HDL-C水平显著高于对照组，差异均有统计学意义(P<0.05)。治疗前，两组血清IL-6、TNF-α、NF-κB水平比较，差异无统计学意义(P>0.05);治疗后，联合组血清IL-6、TNF-α、NF-κB水平均显著低于对照组，差异有统计学意义(P<0.05)。治疗前，两组肝脾CT比值比较，差异无统计学意义(P>0.05);治疗后，联合组肝脾CT比值显著高于对照组，差异有统计学意义(P<0.05)。结论：还原性谷胱甘肽联合熊去氧胆酸治疗非酒精性脂肪肝效果较好，能更有效地降低患者的血脂及炎症指标水平。
【关键词】 还原性谷胱甘肽; 熊去氧胆酸; 非酒精性脂肪肝; 临床效果
doi：10.14033/j.cnki.cfmr.2019.23.003 文献标识码 A 文章编号 1674-6805(2019)23-00-03
【Abstract】 Objective：To investigate the clinical effect of Reduced Glutathione combined with Ursodeoxycholic Acid in the treatment of nonalcoholic fatty liver disease.Method：A total of 120 patients with nonalcoholic fatty liver disease admitted in our hospital from January 2015 to October 2018 were selected and randomly divided into the combined group and the control group by random number table method，with 60 patients in each group.The control group was treated with Reduced Glutathione，and the combined group was treated with Ursodeoxycholic Acid.The changes of liver function，blood lipid index，CT ratio of liver spleen，inflammatory indexes before and after treatment were compared between the two groups.Result：Before treatment，there were no significant differences in serum levels of ALT，AST，TBIL，ALP，GGT between the two groups(P>0.05).After treatment，the serum levels of ALT，AST，TBIL，ALP and GGT in the combined group were significantly lower than those in the control group，the differences were statistically significant(P<0.05).Before treatment，there was no significant difference in serum TC，TG，HDL-C，LDL-C levels between the two groups(P>0.05).After treatment，the serum TC，TG and LDL-C levels in the combined group were significantly lower than those in the control group，and the level of HDL-C was significantly higher than that in the control group，the differences were statistically significant(P<0.05).Before treatment，there was no significant difference in serum IL-6，TNF-α，NF-kappa B levels between the two groups(P>0.05).After treatment，the levels of serum IL-6，TNF-α，NF-kappa B in the combined group were significantly lower than those in the control group，the differences were statistically significant(P<0.05).Before treatment，there was no significant difference in the ratio of liver and spleen CT between the two groups(P>0.05).After treatment，the ratio of liver and spleen CT in the combined group was significantly higher than that in the control group，the difference was statistically significant(P<0.05).Conclusion：The effect of Reduced Glutathione combined with Ursodeoxycholic Acid in the treatment of nonalcoholic fatty liver disease is better，and it can effectively reduce the level of blood lipid and inflammatory indicators in patients., 百拇医药(汪小英 陈馨 王捷军)
【关键词】 还原性谷胱甘肽; 熊去氧胆酸; 非酒精性脂肪肝; 临床效果
doi：10.14033/j.cnki.cfmr.2019.23.003 文献标识码 A 文章编号 1674-6805(2019)23-00-03
【Abstract】 Objective：To investigate the clinical effect of Reduced Glutathione combined with Ursodeoxycholic Acid in the treatment of nonalcoholic fatty liver disease.Method：A total of 120 patients with nonalcoholic fatty liver disease admitted in our hospital from January 2015 to October 2018 were selected and randomly divided into the combined group and the control group by random number table method，with 60 patients in each group.The control group was treated with Reduced Glutathione，and the combined group was treated with Ursodeoxycholic Acid.The changes of liver function，blood lipid index，CT ratio of liver spleen，inflammatory indexes before and after treatment were compared between the two groups.Result：Before treatment，there were no significant differences in serum levels of ALT，AST，TBIL，ALP，GGT between the two groups(P>0.05).After treatment，the serum levels of ALT，AST，TBIL，ALP and GGT in the combined group were significantly lower than those in the control group，the differences were statistically significant(P<0.05).Before treatment，there was no significant difference in serum TC，TG，HDL-C，LDL-C levels between the two groups(P>0.05).After treatment，the serum TC，TG and LDL-C levels in the combined group were significantly lower than those in the control group，and the level of HDL-C was significantly higher than that in the control group，the differences were statistically significant(P<0.05).Before treatment，there was no significant difference in serum IL-6，TNF-α，NF-kappa B levels between the two groups(P>0.05).After treatment，the levels of serum IL-6，TNF-α，NF-kappa B in the combined group were significantly lower than those in the control group，the differences were statistically significant(P<0.05).Before treatment，there was no significant difference in the ratio of liver and spleen CT between the two groups(P>0.05).After treatment，the ratio of liver and spleen CT in the combined group was significantly higher than that in the control group，the difference was statistically significant(P<0.05).Conclusion：The effect of Reduced Glutathione combined with Ursodeoxycholic Acid in the treatment of nonalcoholic fatty liver disease is better，and it can effectively reduce the level of blood lipid and inflammatory indicators in patients., 百拇医药(汪小英 陈馨 王捷军)