IDO在卵巢恶性肿瘤中的研究进展(3)
[6] Frumento G，Rotondo R，Tonetti M，et al.Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2，3-dioxygenase[J].J Exp Med，2002，196(4)：459-468.
[7] Muller A J，DuHadaway J B，Donover P S，et al.Inhibition of indoleamine 2，3-dioxygenase， an immunoregulatory target of the cancer suppression gene Bin1， potentiates cancer chemotherapy[J].Nat Med，2005，11(3)：312-319.
, 百拇医药 [8] Hou D Y，Muller A J，Sharma M D，et al.Inhibition of indoleamine 2，3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses[J].Cancer Res，2007，67(2)：792-801.
[9] Muller A J，Scherle P A.Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors[J].Nat Rev Cancer，2006，6(8)：613-25.
[10]陈勇，陈建国，沈洪兵，等.启东1972～2001年恶性肿瘤发病率时间趋势分析[J].疾病控制杂志，2006，10(2)：105-108.
, 百拇医药
[11] Leung B S，Stout L E，Shaskan E G.Differential induction of indoleamine-2，3-dioxygenase (IDO) by interferon-gamma in human gynecologic cancer cells[J].Cancer Lett，1992，66(1)：77-81.
[12] Okamoto A，Nikaido T，Ochiai K，et al.Indoleamine 2，3-dioxygenase serves as a marker of poor prognosis in gene expression profiles of serous ovarian cancer cells[J].Clin Cancer Res，2005，11(16)：6030-6039.
[13] Takao M，Okamoto A，Nikaido T，et al.Increased synthesis of indoleamine-2，3-dioxygenase protein is positively associated with impaired survival in patients with serous-type， but not with other types of， ovarian cancer[J].Oncol Rep，2007，17(6)：1333-1339.
, 百拇医药
[14] Nonaka H，Saga Y，Fujiwara H，et al.Indoleamine 2，3-dioxygenase promotes peritoneal dissemination of ovarian cancer through inhibition of natural killercell function and angiogenesis promotion[J]. Oncology，2011，38(1)：113-120.
[15] Munn D H，Sharma M D，Hou D，et al.Expression of indoleamine 2，3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes[J].J Clin Invest，2004，114(2)：280-290.
[16] Sharma M D，Baban B，Chandler P，et al.Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2，3-dioxygenase[J].Clin Invest，2007，117(9)：2570-2582.
, 百拇医药
[17] Della C M，Carlomagno S，Frumento G，et al.The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function[J].Blood，2006，108(13)：4118-4125.
[18] Qian F，Villella J，Wallace P K，et al.Efficacy of levo-1-methyl tryptophan and dextro-1-methyl tryptophan in reversing indoleamine-2，3-dioxygenase-mediated arrest of T-cell proliferation in human epithelial ovarian cancer[J].Cancer Res，2009，69(13)：5498-5504.
, http://www.100md.com
[19] Yoshida N，Ino K，Ishida Y，et al.Overexpression of indoleamine 2，3-dioxygenase in human endometrial carcinoma cells induces rapid tumor growth in a mouse xenograft model[J].Clin Cancer Res，2008，14(22)：7251-7259.
[20] Sun J X，Zhang W G，Chen Y X，et al.Indoleamine 2， 3-dioxygenase expression in cells of human acute monocyte leukemia (M(5)) and acute lymphocyte leukemia and therapeutic effect of its inhibitor 1-methyl tryptophan[J].Journal of experimental hematology，2007，15(3)：478-482.
[21] Cheng T C，Manorek G，Samimi G，et al.Identification of genes whose expression is associated with cisplatin resistance in human ovarian carcinoma cells[J].Cancer Chemother Pharmacol，2006，58(3)：384-395.
(收稿日期：2012-05-31) (编辑：田烨), http://www.100md.com(王绍佳 杨宏英)
[7] Muller A J，DuHadaway J B，Donover P S，et al.Inhibition of indoleamine 2，3-dioxygenase， an immunoregulatory target of the cancer suppression gene Bin1， potentiates cancer chemotherapy[J].Nat Med，2005，11(3)：312-319.
, 百拇医药 [8] Hou D Y，Muller A J，Sharma M D，et al.Inhibition of indoleamine 2，3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses[J].Cancer Res，2007，67(2)：792-801.
[9] Muller A J，Scherle P A.Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors[J].Nat Rev Cancer，2006，6(8)：613-25.
[10]陈勇，陈建国，沈洪兵，等.启东1972～2001年恶性肿瘤发病率时间趋势分析[J].疾病控制杂志，2006，10(2)：105-108.
, 百拇医药
[11] Leung B S，Stout L E，Shaskan E G.Differential induction of indoleamine-2，3-dioxygenase (IDO) by interferon-gamma in human gynecologic cancer cells[J].Cancer Lett，1992，66(1)：77-81.
[12] Okamoto A，Nikaido T，Ochiai K，et al.Indoleamine 2，3-dioxygenase serves as a marker of poor prognosis in gene expression profiles of serous ovarian cancer cells[J].Clin Cancer Res，2005，11(16)：6030-6039.
[13] Takao M，Okamoto A，Nikaido T，et al.Increased synthesis of indoleamine-2，3-dioxygenase protein is positively associated with impaired survival in patients with serous-type， but not with other types of， ovarian cancer[J].Oncol Rep，2007，17(6)：1333-1339.
, 百拇医药
[14] Nonaka H，Saga Y，Fujiwara H，et al.Indoleamine 2，3-dioxygenase promotes peritoneal dissemination of ovarian cancer through inhibition of natural killercell function and angiogenesis promotion[J]. Oncology，2011，38(1)：113-120.
[15] Munn D H，Sharma M D，Hou D，et al.Expression of indoleamine 2，3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes[J].J Clin Invest，2004，114(2)：280-290.
[16] Sharma M D，Baban B，Chandler P，et al.Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2，3-dioxygenase[J].Clin Invest，2007，117(9)：2570-2582.
, 百拇医药
[17] Della C M，Carlomagno S，Frumento G，et al.The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function[J].Blood，2006，108(13)：4118-4125.
[18] Qian F，Villella J，Wallace P K，et al.Efficacy of levo-1-methyl tryptophan and dextro-1-methyl tryptophan in reversing indoleamine-2，3-dioxygenase-mediated arrest of T-cell proliferation in human epithelial ovarian cancer[J].Cancer Res，2009，69(13)：5498-5504.
, http://www.100md.com
[19] Yoshida N，Ino K，Ishida Y，et al.Overexpression of indoleamine 2，3-dioxygenase in human endometrial carcinoma cells induces rapid tumor growth in a mouse xenograft model[J].Clin Cancer Res，2008，14(22)：7251-7259.
[20] Sun J X，Zhang W G，Chen Y X，et al.Indoleamine 2， 3-dioxygenase expression in cells of human acute monocyte leukemia (M(5)) and acute lymphocyte leukemia and therapeutic effect of its inhibitor 1-methyl tryptophan[J].Journal of experimental hematology，2007，15(3)：478-482.
[21] Cheng T C，Manorek G，Samimi G，et al.Identification of genes whose expression is associated with cisplatin resistance in human ovarian carcinoma cells[J].Cancer Chemother Pharmacol，2006，58(3)：384-395.
(收稿日期：2012-05-31) (编辑：田烨), http://www.100md.com(王绍佳 杨宏英)