早产儿高胆红素血症与围生期危险因素关系的回顾性分析(1)
【摘要】 目的 探讨分析早产儿高胆红素血症与围生期危险因素的相关性。方法 200例早产儿为研究对象， 检测其血清胆红素， 研究产妇年龄、分娩方式、体重下降情况、母乳情况、产妇孕期妊娠综合征、1 min Apgar评分、胎儿是否发生宫内窘迫等围生期因素， 与早产儿发生新生儿高胆红素血症的关系。结果 不同产妇年龄、分娩方式、体重下降率、母乳情况、产妇孕期妊娠综合征、1 min Apgar评分、胎儿宫内窘迫情况比较， 差异具有统计学意义(P<0.05)。多因素分析显示：高龄、剖宫产、体重下降>10%、母乳不足、胎儿宫内窘迫是早产儿高胆红素血症的危险因素(P<0.05)。结论 在临床治疗中， 要时刻注意产妇年龄、分娩方式、体重下降情况、母乳情况、产妇孕期妊娠综合征、胎儿宫内窘迫等原因， 对早产儿高胆红素血症的发生有警示作用， 减少早产儿高胆红素血症的发生率， 在早产儿高胆红素血症的预防与治疗上有重要意义。
【关键词】 早产儿;高胆红素血症;围生期;危险因素;回顾性分析
DOI：10.14163/j.cnki.11-5547/r.2020.21.015
Retrospective analysis of the correlation between hyperbilirubinemia and perinatal risk factors in preterm infants HUANG Ying-xuan， LI Wei， LIAO Hui-ying， et al. Third Affiliated Hospital of Guangdong Medical University， Foshan 528318， China
【Abstract】 Objective To discuss and analyze the correlation between hyperbilirubinemia and perinatal risk factors in preterm infants. Methods There were 200 preterm infants as study subjects， and their serum bilirubin was detected. The correlation between hyperbilirubinemia and perinatal factors such as maternal age， delivery methods， weight loss， breast milk， maternal pregnancy syndrome， 1 min Apgar score， and whether the fetus had intrauterine distress in preterm infants was studied. Results There was statistically significant difference in maternal age， delivery methods， weight loss， breast milk， maternal pregnancy syndrome， 1 min Apgar score， intrauterine distress (P<0.05). Multiple perinatal risk factors showed that advanced age， cesarean section， weight loss >10%， insufficient breast milk， and intrauterine distress were the risk factors of hyperbilirubinemia in preterm infants (P<0.05). Conclusion In clinical treatment， attention must be paid to maternal age， delivery methods， weight loss， breast milk， maternal pregnancy syndrome， intrauterine distress， which have a warning effect on the occurrence of hyperbilirubinemia in preterm infants， and can reduce the incidence of hyperbilirubinemia in preterm infants. It is of great significance in the prevention and treatment of hyperbilirubinemia in preterm infants.
【Key words】 Preterm infants; Hyperbilirubinemia; Perinatal; Risk factors; Retrospective analysis
早产儿高胆红素血症指婴儿出生时胎龄<37足周， 因婴儿体内有胆红素聚集， 造成巩膜、皮肤或其他器官出现黄染的情况[1]。是新生儿的常见病， 可由多种原因造成， 且发病率较高[2]。因为早产儿器官与系统还未发育完全， 尤其是血脑屏障与肝酶系统， 容易合并早产儿胆红素脑病， 对早产儿的神经系统造成不可逆的伤害， 甚至对早产儿的生命造成威胁， 因此及早对患有高胆红素血症的早产儿进行预防与治疗成为新生儿科的首要任务[3]。溶血症、母乳性黄疸、感染、葡萄糖6-磷酸脱氢酶(G6PD)缺陷病、围生期危险因素是导致早产儿患有高胆红素血症的主要原因， 其中导致早产儿患有高胆红素血症发病率最高的是围生期危险因素[4]。围生期因素包括胎儿宫内窘迫、产妇孕期妊娠综合征、分娩过程中出現难产、窒息、应用催产素及出现颅内出血、缺血缺氧性脑病等并发症[5]。本文探究了早产儿高胆红素血症与围生期危险因素的相关性， 现报告如下。, 百拇医药(黄颖璇 李微 廖惠映 刘玲)
【关键词】 早产儿;高胆红素血症;围生期;危险因素;回顾性分析
DOI：10.14163/j.cnki.11-5547/r.2020.21.015
Retrospective analysis of the correlation between hyperbilirubinemia and perinatal risk factors in preterm infants HUANG Ying-xuan， LI Wei， LIAO Hui-ying， et al. Third Affiliated Hospital of Guangdong Medical University， Foshan 528318， China
【Abstract】 Objective To discuss and analyze the correlation between hyperbilirubinemia and perinatal risk factors in preterm infants. Methods There were 200 preterm infants as study subjects， and their serum bilirubin was detected. The correlation between hyperbilirubinemia and perinatal factors such as maternal age， delivery methods， weight loss， breast milk， maternal pregnancy syndrome， 1 min Apgar score， and whether the fetus had intrauterine distress in preterm infants was studied. Results There was statistically significant difference in maternal age， delivery methods， weight loss， breast milk， maternal pregnancy syndrome， 1 min Apgar score， intrauterine distress (P<0.05). Multiple perinatal risk factors showed that advanced age， cesarean section， weight loss >10%， insufficient breast milk， and intrauterine distress were the risk factors of hyperbilirubinemia in preterm infants (P<0.05). Conclusion In clinical treatment， attention must be paid to maternal age， delivery methods， weight loss， breast milk， maternal pregnancy syndrome， intrauterine distress， which have a warning effect on the occurrence of hyperbilirubinemia in preterm infants， and can reduce the incidence of hyperbilirubinemia in preterm infants. It is of great significance in the prevention and treatment of hyperbilirubinemia in preterm infants.
【Key words】 Preterm infants; Hyperbilirubinemia; Perinatal; Risk factors; Retrospective analysis
早产儿高胆红素血症指婴儿出生时胎龄<37足周， 因婴儿体内有胆红素聚集， 造成巩膜、皮肤或其他器官出现黄染的情况[1]。是新生儿的常见病， 可由多种原因造成， 且发病率较高[2]。因为早产儿器官与系统还未发育完全， 尤其是血脑屏障与肝酶系统， 容易合并早产儿胆红素脑病， 对早产儿的神经系统造成不可逆的伤害， 甚至对早产儿的生命造成威胁， 因此及早对患有高胆红素血症的早产儿进行预防与治疗成为新生儿科的首要任务[3]。溶血症、母乳性黄疸、感染、葡萄糖6-磷酸脱氢酶(G6PD)缺陷病、围生期危险因素是导致早产儿患有高胆红素血症的主要原因， 其中导致早产儿患有高胆红素血症发病率最高的是围生期危险因素[4]。围生期因素包括胎儿宫内窘迫、产妇孕期妊娠综合征、分娩过程中出現难产、窒息、应用催产素及出现颅内出血、缺血缺氧性脑病等并发症[5]。本文探究了早产儿高胆红素血症与围生期危险因素的相关性， 现报告如下。, 百拇医药(黄颖璇 李微 廖惠映 刘玲)