姑息性切除手术治疗中晚期胃癌患者的效果及对体液免疫和临床指标的影响(1)
【摘要】 目的 探討姑息性切除手术治疗中晚期胃癌患者的效果及对体液免疫、临床指标的影响。方法 100例中晚期胃癌患者， 随机分为对照组和观察组， 每组50例。两组患者均给予常规术前准备， 在此基础上， 对照组患者采取姑息性非切除手术治疗， 观察组患者采取姑息性切除手术治疗。比较两组患者生存情况， 术后生活质量评分(心理健康、癌区疼痛、营养情况、活动能力)， 手术前后体液免疫的各指标[免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、补体3(C3)、补体4(C4)]水平。结果 观察组患者术后3、6个月及1年生存率分别为94.00%、80.00%、44.00%， 均明显高于对照组的80.00%、60.00%、20.00%， 差异均有统计学意义(P<0.05)。观察组患者的心理健康、癌区疼痛、营养情况、活动能力评分分别为(78.42±2.45)、(85.46±4.23)、(79.42±4.73)、(79.45±10.00)分， 均明显高于对照组的(58.46±12.45)、(72.45±3.45)、(62.45±5.46)、(61.45±4.72)分， 差异均有统计学意义(P<0.05)。术后1、3 d， 观察组患者的IgG、IgM、C3、C4水平均明显高于对照组， 差异均有统计学意义(P<0.05)。结论 采取姑息性切除手术治疗中晚期胃癌患者的临床疗效显著， 可明显改善机体体液免疫水平， 提高患者生存率及生活质量， 值得在进展期胃癌患者治疗中广泛应用。
【关键词】 姑息性切除手术;胃癌;效果;体液免疫;临床指标
【Abstract】 Objective To discuss the effect of palliative resection for the treatment of patients with advanced gastric cancer and its influence on humoral immunity and clinical indicators. Methods A total of 100 patients with advanced gastric cancer were randomly divided into control group and observation group， with 50 cases in each group. Both groups received routine preoperative preparation. On this basis， the patients in the control group were treated with palliative non-resection surgery， while the patients in the observation group were treated with palliative resection surgery. Comparison was made on survival condition， quality of life score after operation (mental health， cancer pain， nutritional status， mobility)， levels of humoral immunity [immunoglobulin G (IgG)， immunoglobulin M (IgM)， complement 3 (C3)， complement 4 (C4)] before and after operation between the two groups. Results The observation group had obviously higher survival rate 3 and 6 months and 1 year after operation respectively as 94.00%， 80.00% and 44.00% than 80.00%， 60.00% and 20.00% in the control group， and their difference was statistically significant (P<0.05). The observation group had obviously higher mental health， cancer pain， nutritional status， mobility score respectively as (78.42±2.45)， (85.46±4.23)， (79.42±4.73) and (79.45±10.00) points than (58.46±12.45)， (72.45±3.45)， (62.45±5.46) and (61.45±4.72) points in the control group， and their difference was statistically significant (P<0.05). 1 and 3 d after operation， the observation group had obviously higher IgG， IgM， C3 and C4 than those of the control group， and their difference was statistically significant (P<0.05). Conclusion Palliative resection surgery has significant effect on patients with advanced gastric cancer， and it can obviously improve the level of humoral immunity， improve the survival rate and quality of life of patients. It is worthy of wide application in the treatment of patients with advanced gastric cancer., 百拇医药(董明明 刘瑞枝 何代捷)
【关键词】 姑息性切除手术;胃癌;效果;体液免疫;临床指标
【Abstract】 Objective To discuss the effect of palliative resection for the treatment of patients with advanced gastric cancer and its influence on humoral immunity and clinical indicators. Methods A total of 100 patients with advanced gastric cancer were randomly divided into control group and observation group， with 50 cases in each group. Both groups received routine preoperative preparation. On this basis， the patients in the control group were treated with palliative non-resection surgery， while the patients in the observation group were treated with palliative resection surgery. Comparison was made on survival condition， quality of life score after operation (mental health， cancer pain， nutritional status， mobility)， levels of humoral immunity [immunoglobulin G (IgG)， immunoglobulin M (IgM)， complement 3 (C3)， complement 4 (C4)] before and after operation between the two groups. Results The observation group had obviously higher survival rate 3 and 6 months and 1 year after operation respectively as 94.00%， 80.00% and 44.00% than 80.00%， 60.00% and 20.00% in the control group， and their difference was statistically significant (P<0.05). The observation group had obviously higher mental health， cancer pain， nutritional status， mobility score respectively as (78.42±2.45)， (85.46±4.23)， (79.42±4.73) and (79.45±10.00) points than (58.46±12.45)， (72.45±3.45)， (62.45±5.46) and (61.45±4.72) points in the control group， and their difference was statistically significant (P<0.05). 1 and 3 d after operation， the observation group had obviously higher IgG， IgM， C3 and C4 than those of the control group， and their difference was statistically significant (P<0.05). Conclusion Palliative resection surgery has significant effect on patients with advanced gastric cancer， and it can obviously improve the level of humoral immunity， improve the survival rate and quality of life of patients. It is worthy of wide application in the treatment of patients with advanced gastric cancer., 百拇医药(董明明 刘瑞枝 何代捷)