脑出血术后应用依达拉奉疗效分析(1)
【摘要】 目的 观察依达拉奉注射液应用于脑出血术后患者的疗效。方法 78例脑出血术后患者随机分为治疗组(39例)和对照组(39例)。对照组给予常规治疗， 治疗组在常规治疗基础上加用依达拉奉注射液治疗。分别于治疗前及治疗后2、4周进行神经功能缺损评分(NIHSS)， 3个月后行日常生活能力评分(BI)， 并进行统计学分析。结果 治疗组治疗2、4周NIHSS分别为(11.7±3.5)、(8.9±3.1)分；对照组NIHSS分别为(15.7±4.6)、(13.2±3.4)分， 两组比较差异有统计学意义(P<0.01)。3个月后治疗组BI显效率为61.54%、有效率为84.62%；对照组BI显效率为38.46%、有效率为64.10%， 两组比较差异有统计学意义(P<0.01)。结论 依达拉奉能促进脑出血术后患者的神经功能康复， 且安全有效。
【关键词】 依达拉奉；脑出血术后；神经功能缺损
DOI：10.14163/j.cnki.11-5547/r.2015.17.020
, http://www.100md.com
Analysis of curative effect by edaravone applied after cerebral hemorrhage operation WANG Shi-qiang， ZHANG Qi-hui， SONG Tong-jun， et al. Department of Neurosurgery， Affiliated Shenzhen Shajing Hospital of Guangzhou Medical University， Shenzhen 518104， China
【Abstract】 Objective To observe the curative effect of edaravone injection in the treatment of patients after cerebral hemorrhage operation. Methods A total of 78 patients after cerebral hemorrhage operation were randomly divided into treatment group (39 cases) and control group (39 cases). The control group received conventional treatment， and the treatment group received additional 30 mg of edaravone injection for treatment. National institutes of health stroke scale (NIHSS) was applied before treatment and in 2 and 4 weeks after treatment， and Barthel index (BI) was applied after 3 months. The scores were statistically analyzed. Results The treatment group had NIHSS scores in 2 and 4 weeks as respectively (11.7±3.5) and (8.9±3.1) points， and those of the control group were (15.7±4.6) and (13.2±3.4) points. The difference between the two groups had statistical significance (P<0.01). After 3 months， the excellent rate of BI was 61.54% in the treatment group， and its effective rate was 84.62%. The control group had excellent rate as 38.46% and effective rate as 64.10%. The difference between the two groups had statistical significance (P<0.01). Conclusion Edaravone can accelerate rehabilitation of neurological function after cerebral hemorrhage operation， with safety and effectiveness.
, http://www.100md.com
【Key words】 Edaravone； After cerebral hemorrhage operation； Neurologic impairment
脑出血(cerebral hemorrhage)严重危害人类健康， 在我国发病率较高， 早期、超早期手术清除血肿是神经外科医生治疗脑出血的有效方法， 术后的病理变化是多因素参与的复杂过程， 其中自由基是脑出血后产生的毒性物质之一， 依达拉奉可清除自由基， 抑制脂质过氧化， 从而抑制脑细胞、血管内皮细胞、神经细胞的氧化损伤[1]。本科脑出血术后患者应用依达拉奉注射液治疗取得良好疗效， 现报告如下。
1 资料与方法
1. 1 一般资料 病例为本科2011年12月～2014年11月收治的78例高血压基底节脑出血患者， 术前格拉斯哥昏迷评分(GCS评分)5～14分， 颅脑CT均已经证实， 出血量约30～72 ml， 入院至手术时机选择发病后4～24 h， 符合1995年全国第四届脑血管病学术会议关于脑出血的诊断标准， 且无再出血发生、无重要脏器功能障碍。所有患者随机分为对照组和治疗组， 各39例。两组年龄、GCS评分、血肿量等一般资料比较差异无统计学意义(P>0.05)， 具有可比性。, http://www.100md.com(王士强 张琦辉 宋同均 刘裕浩 董世节)
【关键词】 依达拉奉；脑出血术后；神经功能缺损
DOI：10.14163/j.cnki.11-5547/r.2015.17.020
, http://www.100md.com
Analysis of curative effect by edaravone applied after cerebral hemorrhage operation WANG Shi-qiang， ZHANG Qi-hui， SONG Tong-jun， et al. Department of Neurosurgery， Affiliated Shenzhen Shajing Hospital of Guangzhou Medical University， Shenzhen 518104， China
【Abstract】 Objective To observe the curative effect of edaravone injection in the treatment of patients after cerebral hemorrhage operation. Methods A total of 78 patients after cerebral hemorrhage operation were randomly divided into treatment group (39 cases) and control group (39 cases). The control group received conventional treatment， and the treatment group received additional 30 mg of edaravone injection for treatment. National institutes of health stroke scale (NIHSS) was applied before treatment and in 2 and 4 weeks after treatment， and Barthel index (BI) was applied after 3 months. The scores were statistically analyzed. Results The treatment group had NIHSS scores in 2 and 4 weeks as respectively (11.7±3.5) and (8.9±3.1) points， and those of the control group were (15.7±4.6) and (13.2±3.4) points. The difference between the two groups had statistical significance (P<0.01). After 3 months， the excellent rate of BI was 61.54% in the treatment group， and its effective rate was 84.62%. The control group had excellent rate as 38.46% and effective rate as 64.10%. The difference between the two groups had statistical significance (P<0.01). Conclusion Edaravone can accelerate rehabilitation of neurological function after cerebral hemorrhage operation， with safety and effectiveness.
, http://www.100md.com
【Key words】 Edaravone； After cerebral hemorrhage operation； Neurologic impairment
脑出血(cerebral hemorrhage)严重危害人类健康， 在我国发病率较高， 早期、超早期手术清除血肿是神经外科医生治疗脑出血的有效方法， 术后的病理变化是多因素参与的复杂过程， 其中自由基是脑出血后产生的毒性物质之一， 依达拉奉可清除自由基， 抑制脂质过氧化， 从而抑制脑细胞、血管内皮细胞、神经细胞的氧化损伤[1]。本科脑出血术后患者应用依达拉奉注射液治疗取得良好疗效， 现报告如下。
1 资料与方法
1. 1 一般资料 病例为本科2011年12月～2014年11月收治的78例高血压基底节脑出血患者， 术前格拉斯哥昏迷评分(GCS评分)5～14分， 颅脑CT均已经证实， 出血量约30～72 ml， 入院至手术时机选择发病后4～24 h， 符合1995年全国第四届脑血管病学术会议关于脑出血的诊断标准， 且无再出血发生、无重要脏器功能障碍。所有患者随机分为对照组和治疗组， 各39例。两组年龄、GCS评分、血肿量等一般资料比较差异无统计学意义(P>0.05)， 具有可比性。, http://www.100md.com(王士强 张琦辉 宋同均 刘裕浩 董世节)