P38mAPK信号通路在糖尿病肾病中的作用(2)
 |
| 第1页 |
参见附件。
本研究从分子机制方面探讨了高血糖引起肾小球系膜细胞MMP—9和TIMP—1表达变化是通过p38 mAPK信号通路实现的，这一发现为开展今后糖尿病肾病的防治及新药研发提供了新思路。
参 考 文 献
[1] Wu Z， Xiong Y， Gajanayake T， et al. p38 Mitogen—Activated Protein Kinase Is Required for Glucosamine—Induced Endothelial Nitric Oxide Synthase Uncoupling and Plasminogen—Activator Inhibitor Expression. Circ J， 2012，76(8)：2015—2522.
[2] Harrell NB， Teachey MK， Gifford NJ， et al. Essential role of p38 MAPK for activation of skelet al muscle glucose tRNAsport by lithium. Arch Physiol Biochem， 2007， 113(4—5)：221—227.
[3] Serum matrix met alloproteinases MMP—2 and MMP—9 and met alloproteinase tissue inhibitors TIMP—1 and TIMP—2 in diabetic nephropathy. J Nephrol， 2007，20(4)：444—452.
[4] Martin J， Knowlden J， Devies M， et al. Identification and independent regulation of human mesangial cells met alloproteinases. Kidney Int， 1994， 46(3)：877—885.
[5] Rysz J， Banach M， Stolarek RA，et al. Serum matrix met alloproteinases MMP—2 and MMP—9 and met alloproteinase tissue inhibitors TIMP—1 and TIMP—2 in diabetic nephropathy. J Nephrol， 2007，20(4)：444—452.
[6] Harrell NB， Teachey MK， Gifford NJ， et al. Essential role of p38 MAPK for activation of skelet al muscle glucose tRNAsport by lithium. Arch Physiol Biochem， 2007， 113(4—5)：221—227.
[7] Wang X， Goh CH， Li B.p38 mitogen—activated protein kinase regulates osteoblast differentiation through osterix. Endocrinology， 2007，148(4)：1629—1637.
[8] Kang SW， Adler SG，Lapage J， et al. P38 MAPK and MAPK kinase 3/6 mRNA and activities are increased in early diabetic glomeruli. Kidney Int， 2001， 60(2)：543—552.
您现在查看是摘要介绍页，详见PDF附件(2479kb)。