苯磺酸左旋氨氯地平与瑞舒伐他汀钙对原发性高血压病患者颈动脉粥样硬化的影响(1)
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【摘要】 目的 探讨苯磺酸左旋氨氯地平与瑞舒伐他汀钙联合治疗对原发性高血压病患者颈动脉硬化的影响。方法 选择2009年2月至2010年2月原发性高血压并颈动脉硬化患者80例，随机分为对照组(40例)和试验组(40例)。对照组使用苯磺酸左旋氨氯地平2.5 mg，1次/d，2周后，血压未达标者，增加剂量至5 mg，试验组同时口服瑞舒伐他汀钙10 mg，1次/晚，疗程为48周。比较两组治疗前、后的颈动脉IMT、血压、血脂、hsCRP的变化。结果 服药48周后，两组IMT、BP均较治疗前明显降低(P<0.05)；其中试验组IMT降低更明显(P<0.05)。试验组TG、TC、LDL-C、hsCRP明显下降，HDL-C明显增高，与治疗前及对照组治疗前、后比较，差异均有统计学意义(P<0.05)。结论 苯磺酸左旋氨氯地平与瑞舒伐他汀钙联合对颈动脉IMT作用明显，能有效延缓﹑逆转原发性高血压病患者颈动脉粥样硬化进展。
【关键词】 原发性高血压病；颈动脉粥样硬化；苯磺酸左旋氨氯地平；瑞舒伐他汀钙
Effect of Levamlodipine Besylate and Rosuvastatin Calcium on carotid arteriosclerosis in patients with essential hypertension
ZHU Chao, LI Chun-feng. Affiliated Hospital of Xuzhou Medical College, Xu Zhou 221006,China
【Abstract】 Objective To explore the effect of Levamlodipine Bsylate and Rosuvastatin Calcium on carotid artery intima-media thickness(IMT) in patients with essential hypertension. Methods 80 patinets with essential hypertension complicated with carotid arteriosclerosis were randomly divided into control group(40 cases) and experimental group(40 cases).Patients in control group were treated with Levamlodipine Bsylate 2.5 mg qd,and the dosage was added to 5 mg qd if the blood pressure was above 140/90 mm Hg after 2 weeks treatment.Patients in the experimental group were given Rosuvastatin Calcium 10 mg qn for 48weeks.The IMT of carotid artery, blood pressure, levels of TC, TG, LDL-C, HDL-C, hs-CRP were monitored before and after treatment, ResultsThe IMT and blood pressure decreased obviously in two groups 48 weeks after treatment(P<0.05)and IMT decreased significantly in experimental group compared with that of control group(P<0.05). Level of TG, TC, LDL-C and hs-CRP decreased,and HDL-C increased significantly in experimental group than those in control group and before treament(P<0.05). Conclusion Combined application of Levamlodipine Besylate and Rosuvastatin Calcium has significant effect on IMT of carotid in patients with essental hypertension and it can delay the progression of essential hypertension.
【Key words】 Essential hypertension; Carotid arteriosclerosis; Levamlodipine Besylate; Rosuvastatin Calcium ......
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