糖尿病肾病相关药物研究进展
【摘要】 糖尿病肾病(DN)是糖尿病重要微血管并发症，其病理特征性表现为肾小球周边部位出现嗜酸性K-W结节，是糖尿病性肾病具有诊断意义的改变。但仅出现于约10%~20%的糖尿病性肾病患者。糖尿病性肾病其他病理改变特点包括肾小球基膜增厚，肾小球上皮细胞足突融合以及由于细胞外系膜基质增多所致肾小球增大。疾病晚期可出现肾小管萎缩肾内纤维化。糖尿病病程10年以上者约50%并发糖尿病肾病，每年新增终末期肾病中，糖尿病导致者所占比例逐年增高。近年关于血管紧张素转换酶抑制剂(ACEI)治疗糖尿病肾病的研究较多。其外内皮素拮抗剂等，被认为有一定的肾脏保护作用，基因治疗亦给糖尿病肾病带来新希望。现就有关内容综述如下。【关键词】
糖尿病肾病；血管紧张素转换抑制剂；基本治疗；综述
【Abstract】 Objective Diabetic nephropathy (DN) is an important microvascular complications of diabetes, the pathological features of the performance of the peripheral parts of the glomerular eosinophilic KW nodule appears, is the diagnosis of diabetic nephropathy has changed. But only appeared in about 10% to 20% of patients with diabetic nephropathy. Other pathological changes of diabetic nephropathy include glomerular basement membrane thickening characteristics of the glomerular epithelial cell foot process fusion as a Results of increased extracellular caused by glomerular mesangial matrix increase. Advanced disease, renal fibrosis and tubular atrophy may occur. More than 10 years duration of diabetes of approximately 50% of the complicated diabetic nephropathy, an annual increase of end-stage renal disease, diabetes caused by increasing the proportion of each year. In recent years, on the angiotensin-converting enzyme inhibitor (ACEI) treatment of diabetic nephropathy more. Its external endothelin antagonist, is said to have some protective effect of kidney, gene therapy has brought new hope to diabetic nephropathy. Now the contents are summarized below. ......
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