老年冠心病患者MTHFR基因多态性研究(1)
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【摘要】 目的 探讨N5,N10亚甲基四氢叶酸还原酶(MTHFR)基因多态性与老年冠心病的关系。方法 应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)检测114例冠心病患者及31例对照组MTHFR基因多态性。结果 冠心病组与对照组MTHFR基因C677T位点各基因型频率、T等位基因频率、T/T纯合子频率差异无显著性差异。结论MTHFR基因多态性与老年冠心病无显著关系,不能被确定为老年冠心病的独立危险因素。
【关键词】
MTHFR基因多态性;冠心病
The relationship between coronary heart disease and methylenetetrahy drofolate reductase in elderlyLI Xiao-bo,LI Yan,LI Ya-ping,et al.Department of Senior Cadres,The First People’s Hospital of Yunnan Province,Kunming 650032,Chia
【Abstract】 Objective To observe the relationship of polymorphisms in methylenetetrahydrofolate reductase(MTHFR)and coronary heart disease(CHD)in the elderly.Methods Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)was used to analyze the MTHFR C677T genotypes in a sample of 114 cases with documented CHD and 31 controls among the elderly patients.Results There were no differences in genotype frequency or allele frequencies between CHD and the control ......
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