氨曲南治疗下呼吸道感染的临床疗效观察(2)
下呼吸道感染不容易得到有效控制的主要原因是细菌耐药，尤其是对铜绿假单胞菌、肺炎克雷伯杆菌、大肠埃希菌等医院内获得性细菌，更易产生耐药性。氨曲南对革兰阴性杆菌有较好的抗菌活性，可能是由于其独特的单环化学结构，对β-内酰胺酶稳定性大为提高，更容易穿透细菌细胞壁，具有明显的杀菌效应所致，特别是对大肠埃希菌、肺炎克雷伯杆菌、肠杆菌属具有高度的抗菌活性，对铜绿假单胞菌也有良好的抗菌活性[4]。本试验通过比较观察氨曲南和头孢吡肟对下呼吸道感染的临床疗效发现，氨曲南对下呼吸道感染的疗效满意，不良反应少，药物安全性高，值得在临床推广应用。
参考文献
[1] Jens K,Moller，Mogens K.Antibiotic treatment and the diagnosis of Streptococcus pneumoniae in lower respiratory tract infections in adults.International Journal of Infectious Diseases,2005,9(5):274.
[2] 张波,刘刚,府伟灵,等.呼吸病房下呼吸道感染病原菌监测及耐药性.中华医院感染学杂志,2006,16(11):1302-1304.
[3] Helio SS,Ronald NJ.Comprehensive in vitro evaluation of cefepime combined with aztreonam or ampicillin/sulbactam against multi-drug resistant Pseudomonas aeruginosa and acinetobacter spp.International Journal of Antimicrobial Agents,2005,25(5):380.
[4] Helio SS,Holly KH,Ronald NJ.Contemporary in vitro synergy rates for aztreonam combined with newer fluoroquinolones and β-lactams tested against gram-negative bacilli.Diagnostic Microbiology and Infectious Diseases,2003,47(3):547., 百拇医药(尹成芳)
参考文献
[1] Jens K,Moller，Mogens K.Antibiotic treatment and the diagnosis of Streptococcus pneumoniae in lower respiratory tract infections in adults.International Journal of Infectious Diseases,2005,9(5):274.
[2] 张波,刘刚,府伟灵,等.呼吸病房下呼吸道感染病原菌监测及耐药性.中华医院感染学杂志,2006,16(11):1302-1304.
[3] Helio SS,Ronald NJ.Comprehensive in vitro evaluation of cefepime combined with aztreonam or ampicillin/sulbactam against multi-drug resistant Pseudomonas aeruginosa and acinetobacter spp.International Journal of Antimicrobial Agents,2005,25(5):380.
[4] Helio SS,Holly KH,Ronald NJ.Contemporary in vitro synergy rates for aztreonam combined with newer fluoroquinolones and β-lactams tested against gram-negative bacilli.Diagnostic Microbiology and Infectious Diseases,2003,47(3):547., 百拇医药(尹成芳)