阻断Notch信号的角质形成细胞对成纤维细胞增殖及分泌功能的影响研究(4)
[7]Nowinski D，Hoijer P，Engstrand T，et al.Keratinocytes inhibit expression of
connective tissue growth factor in fibroblasts in vivo by an interleukin-lα-dq)endent mechanism[J]J Invest Dermatol，2002，l 19(2)：449-455.
[8]Rangarajan A，Talora C，Okuyama R，et al.Notch signaling is adirect determinant of keratinocyte growth arrest and entry into
differentiation[J].EMBO J，2001，20(13)：3427-3436.
, http://www.100md.com
[9]Dotto GRNotch tumor suppressor function[J].Oncogene，2008，27(38)：5115-5123.
[10]夏煒，潘宝华，刘宾，等.Notch信号在增生性瘢痕表皮中的表达[J].中华整形外科杂志，2009，25(1)：41-45.
[11]Li Bing，Guo Shuzhong，Xia Wei，et al.Blocking Notch signal pathwaysuppress profibrotic growth factor production in keratinocyte [J].Chinese JAesthet Med，2012，21(4)：576-579.
[12]刁建升，张曦，夏炜，等.阻断Notch信号对兔耳增生性瘢痕形成的影响及作用机制[J].中华整形外科杂志，2009，89(16)：1088-1092.
, 百拇医药
[13]Lowell S，Jones P，Le Roux I，et al.Stimulation of human epidermaldifferentiation by Deltα-Notch signaling at the boundaries of stem-cell clusters [J].Curr Biol，2000，10(9)：491-500.
[14]Ryubei Okuyama，Hachiro Tagami，Setsuya Aiba.Notch signaling：Its role in epidermal homeostasis and in pathogenesis of skindiseases[J].J Dermatol Sci，2008，49(3)： 187-194.
[15]Lim IJ，Phan TT，Song C，et al.Investigation of the influence ofkeloid-derived keratinocyte on fibroblast growth and proliferation invitro[J].Plast Reconstr Surg，2001，107(3)：797-808.
, 百拇医药
[16]Shi C，Zhu J，Yang D.The pivotal role of inflammation in scar/keloidformation after acne[J].Dermatoendocrinol，2018，9(l)：el448327.
[17]Leavitt T，Hu MS，Marshall CD，et al.Scarless wound healingrfindingthe right cells and signals[J].Cell Tissue Res，2016，365(3)：483-493.
[18]Ma X，Chen J，Xu B，et aLKeloid-derived keratinocytes acquire a fibroblast-like appearance and an enhanced invasive capacity in a hypoxicmicroenvironment in vitro[J].Int J Mol Med，2015，35(5)： 1246-1256.
, 百拇医药
[19]Jiao Y，Wang X，Zhang J，et al.Inhibiting function of human fetal dermalmesenchymal stem cells on bioactivities of keloid fibroblasts [J].StemCell Res Ther，2017，8(1)：170.
[20]Wu N，Rollin J，Masse I，et al.p63 regulates human keratinocyteproliferation via MYC-regulated gene network and differentiationcommitment through cell adhesion-related gene network[J].J BiolChem，2012，287(8)：5627-5638.
[21]Dong S，Sun Y.MicroRNΑ-22 may promote apoptosis and inhibit theproliferation of hypertrophic scar fibroblasts by regulating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase/p21pathway [J].Exp Ther Med，2017，14(4)：3841-3845.
, 百拇医药
[22]Luo L，Li J，Liu H，et al.Adiponectin is involved in connective tissuegrowth factor-induced proliferation，migration and overproduction of theextracellular matrix in keloid fibroblasts[J].Int J Moi Sci，2017，18(5)：el044.
[23]Wang X，Cao P，Liu J，et al.5-Aminolaevulinic acid-based photodynamictherapy restrains pathological hyperplasia of fibroblasts [J]， Med SciMonit，2017，23：46-56.
[24]Jiao H，Dong P，Yan L，et al.TGF-pi induces polypyrimidine tract-binding protein to alter fibroblasts proliferation and fibronectindeposition in keloid[J].Sci Rep，2016，6：38033.
, 百拇医药
[25]Wang W，Qu M，Xu L，et al.Sorafenib exerts an anti-keloid activity byantagonizing TGF-p/Smad and MAPK/ERK signaling pathways[J].JMol Med(Berl).2016，94(10)： 1181-1194.
[26]Farhatullah S，Ardeshir B.Notch signaling pathway in keloid disease：Enhanced fibroblast activity in a Jagged-1 peptide-dependentmanner in lesional vs.extralesional fibroblasts[J].Wound RepairRegen，2012，20(5)：688-706., 百拇医药(楚菲菲 王大雷 闫伦 李辉超 夏炜 马显杰)
connective tissue growth factor in fibroblasts in vivo by an interleukin-lα-dq)endent mechanism[J]J Invest Dermatol，2002，l 19(2)：449-455.
[8]Rangarajan A，Talora C，Okuyama R，et al.Notch signaling is adirect determinant of keratinocyte growth arrest and entry into
differentiation[J].EMBO J，2001，20(13)：3427-3436.
, http://www.100md.com
[9]Dotto GRNotch tumor suppressor function[J].Oncogene，2008，27(38)：5115-5123.
[10]夏煒，潘宝华，刘宾，等.Notch信号在增生性瘢痕表皮中的表达[J].中华整形外科杂志，2009，25(1)：41-45.
[11]Li Bing，Guo Shuzhong，Xia Wei，et al.Blocking Notch signal pathwaysuppress profibrotic growth factor production in keratinocyte [J].Chinese JAesthet Med，2012，21(4)：576-579.
[12]刁建升，张曦，夏炜，等.阻断Notch信号对兔耳增生性瘢痕形成的影响及作用机制[J].中华整形外科杂志，2009，89(16)：1088-1092.
, 百拇医药
[13]Lowell S，Jones P，Le Roux I，et al.Stimulation of human epidermaldifferentiation by Deltα-Notch signaling at the boundaries of stem-cell clusters [J].Curr Biol，2000，10(9)：491-500.
[14]Ryubei Okuyama，Hachiro Tagami，Setsuya Aiba.Notch signaling：Its role in epidermal homeostasis and in pathogenesis of skindiseases[J].J Dermatol Sci，2008，49(3)： 187-194.
[15]Lim IJ，Phan TT，Song C，et al.Investigation of the influence ofkeloid-derived keratinocyte on fibroblast growth and proliferation invitro[J].Plast Reconstr Surg，2001，107(3)：797-808.
, 百拇医药
[16]Shi C，Zhu J，Yang D.The pivotal role of inflammation in scar/keloidformation after acne[J].Dermatoendocrinol，2018，9(l)：el448327.
[17]Leavitt T，Hu MS，Marshall CD，et al.Scarless wound healingrfindingthe right cells and signals[J].Cell Tissue Res，2016，365(3)：483-493.
[18]Ma X，Chen J，Xu B，et aLKeloid-derived keratinocytes acquire a fibroblast-like appearance and an enhanced invasive capacity in a hypoxicmicroenvironment in vitro[J].Int J Mol Med，2015，35(5)： 1246-1256.
, 百拇医药
[19]Jiao Y，Wang X，Zhang J，et al.Inhibiting function of human fetal dermalmesenchymal stem cells on bioactivities of keloid fibroblasts [J].StemCell Res Ther，2017，8(1)：170.
[20]Wu N，Rollin J，Masse I，et al.p63 regulates human keratinocyteproliferation via MYC-regulated gene network and differentiationcommitment through cell adhesion-related gene network[J].J BiolChem，2012，287(8)：5627-5638.
[21]Dong S，Sun Y.MicroRNΑ-22 may promote apoptosis and inhibit theproliferation of hypertrophic scar fibroblasts by regulating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase/p21pathway [J].Exp Ther Med，2017，14(4)：3841-3845.
, 百拇医药
[22]Luo L，Li J，Liu H，et al.Adiponectin is involved in connective tissuegrowth factor-induced proliferation，migration and overproduction of theextracellular matrix in keloid fibroblasts[J].Int J Moi Sci，2017，18(5)：el044.
[23]Wang X，Cao P，Liu J，et al.5-Aminolaevulinic acid-based photodynamictherapy restrains pathological hyperplasia of fibroblasts [J]， Med SciMonit，2017，23：46-56.
[24]Jiao H，Dong P，Yan L，et al.TGF-pi induces polypyrimidine tract-binding protein to alter fibroblasts proliferation and fibronectindeposition in keloid[J].Sci Rep，2016，6：38033.
, 百拇医药
[25]Wang W，Qu M，Xu L，et al.Sorafenib exerts an anti-keloid activity byantagonizing TGF-p/Smad and MAPK/ERK signaling pathways[J].JMol Med(Berl).2016，94(10)： 1181-1194.
[26]Farhatullah S，Ardeshir B.Notch signaling pathway in keloid disease：Enhanced fibroblast activity in a Jagged-1 peptide-dependentmanner in lesional vs.extralesional fibroblasts[J].Wound RepairRegen，2012，20(5)：688-706., 百拇医药(楚菲菲 王大雷 闫伦 李辉超 夏炜 马显杰)