基于复杂网络等方法的十九畏人参五灵脂同方配伍探析(1)
[摘要]為探讨十九畏中人参五灵脂同方配伍应用特点以及古今配伍的差异，整理1949—2016年现代文献中人参五灵脂同方配伍的应用，运用无尺度复杂网络等数据挖掘方法对其进行分析，并与历代人参五灵脂同方方剂对照。结果表明十九畏中人参五灵脂这一组药物不是绝对的配伍禁忌。1949—2016年人参五灵脂同方应用报道中人参五灵脂同方主要应用于治疗气虚血瘀证的恶性肿瘤、冠心病等；方中常配伍益气补血、活血止痛功效的药物，复杂网络关系显示与人参五灵脂联系最为密切的药物为甘草、当归、黄芪、蒲黄、丹参，其次是白芍、白术、桃仁、茯苓等，外围还有红花、三七、香附、柴胡等；核心药对为人参甘草、五灵脂甘草、人参当归、五灵脂当归、人参黄芪、五灵脂黄芪等，人参五灵脂甘草，人参五灵脂当归，人参五灵脂黄芪，人参五灵脂蒲黄等药组支持度较高。古今人参五灵脂同方方剂中的主要药物配伍存在差异，现代方剂中频繁使用三七、蒲黄、丹参、黄芪等，古代应用较少，古今比较显示现代更为注重配伍活血益气药。
[关键词]十九畏； 人参五灵脂； 应用特点； 无尺度复杂网络方法
, 百拇医药
Research on compatibility of prescriptions including Ginseng Radix et
Rhizoma and Trogopterus Dung based on complex network analysis
LI Mengwen1，2， FAN Xinsheng1，2*， ZHANG Lingshan1，2， WANG Congjun3
1. Institute of Traditional Chinese Medicine Literature Research， Nanjing University of Chinese Medicine， Nanjing 210023， China；
2. School of Basic Medicine， Nanjing University of Chinese Medicine， Nanjing 210023， China；
, 百拇医药
3. Key Laboratory of Computer Software New Technology National， Nanjing University， Nanjing 210046， China)
[Abstract]The applications of prescriptions including Ginseng Radix et Rhizoma and Trogopterus Dung in contemporary literatures from 1949 to 2016 are compiled and the data mining techniques containing scalefree complex network method are utilized to explore its practical characteristics， with comparison between modern and ancient ones. The results indicate that malignant neoplasms， coronary heart disease which present Qi deficiency and blood stasis type are the main diseases treated by prescriptions including Ginseng Radix et Rhizoma and Trogopterus Dung according to the reports during 1949 to 2016. The complex network connection shows that Glycyrrhizae Radixet Rhizoma， Angelicae Sinensis Radix， Astragali Radix， Typhae Pollen， Salviae Miltiorrhizae Radix et Rhizoma are the primary drugs related to Ginseng Radix et Rhizoma and Trogopterus Dung. The next are Paeoniae Radix Alba， Atractylodis Macrocephalae Rhizoma， Persicae Semen， Foria， et al. Carthami Flos， Notoginseng Radix et Rhizoma， Cyperi Rhizoma， Bupleuri Radix are the peripheral ones. Also， Ginseng Radix et RhizomaGlycyrrhizae Radixet Rhizoma， Trogopterus DungGlycyrrhizae Radixet Rhizoma， Ginseng Radix et RhizomaAngelicae Sinensis Radix， Trogopterus DungAngelicae Sinensis Radix， Ginseng Radix et RhizomaAstragali Radix， Trogopterus DungAstragali Radix are the main paired drugs. The paired drugs including Ginseng Radix et RhizomaTrogopterus DungGlycyrrhizae Radixet Rhizoma， Ginseng Radix et RhizomaTrogopterus DungAngelicae Sinensis Radix， Ginseng Radix et RhizomaTrogopterus DungAstragali Radix， Ginseng Radix et RhizomaTrogopterus DungTyphae Pollen have a higher support degree. The main compatible drugs are different in ancient and modern prescriptions including Ginseng Radix et Rhizoma and Trogopterus Dung. Notoginseng Radix et Rhizoma， Typhae Pollen， Salviae Miltiorrhizae Radix et Rhizoma， Astragali Radix are utilized frequently in modern prescriptions while less used in ancient ones. It is also shown that more attentions are paid to the drugs contributing to invigorating Qi and promoting blood circulation in modern times with comparative results between modern and ancient prescriptions., 百拇医药(李梦雯范欣生张泠杉王崇骏)
[关键词]十九畏； 人参五灵脂； 应用特点； 无尺度复杂网络方法
, 百拇医药
Research on compatibility of prescriptions including Ginseng Radix et
Rhizoma and Trogopterus Dung based on complex network analysis
LI Mengwen1，2， FAN Xinsheng1，2*， ZHANG Lingshan1，2， WANG Congjun3
1. Institute of Traditional Chinese Medicine Literature Research， Nanjing University of Chinese Medicine， Nanjing 210023， China；
2. School of Basic Medicine， Nanjing University of Chinese Medicine， Nanjing 210023， China；
, 百拇医药
3. Key Laboratory of Computer Software New Technology National， Nanjing University， Nanjing 210046， China)
[Abstract]The applications of prescriptions including Ginseng Radix et Rhizoma and Trogopterus Dung in contemporary literatures from 1949 to 2016 are compiled and the data mining techniques containing scalefree complex network method are utilized to explore its practical characteristics， with comparison between modern and ancient ones. The results indicate that malignant neoplasms， coronary heart disease which present Qi deficiency and blood stasis type are the main diseases treated by prescriptions including Ginseng Radix et Rhizoma and Trogopterus Dung according to the reports during 1949 to 2016. The complex network connection shows that Glycyrrhizae Radixet Rhizoma， Angelicae Sinensis Radix， Astragali Radix， Typhae Pollen， Salviae Miltiorrhizae Radix et Rhizoma are the primary drugs related to Ginseng Radix et Rhizoma and Trogopterus Dung. The next are Paeoniae Radix Alba， Atractylodis Macrocephalae Rhizoma， Persicae Semen， Foria， et al. Carthami Flos， Notoginseng Radix et Rhizoma， Cyperi Rhizoma， Bupleuri Radix are the peripheral ones. Also， Ginseng Radix et RhizomaGlycyrrhizae Radixet Rhizoma， Trogopterus DungGlycyrrhizae Radixet Rhizoma， Ginseng Radix et RhizomaAngelicae Sinensis Radix， Trogopterus DungAngelicae Sinensis Radix， Ginseng Radix et RhizomaAstragali Radix， Trogopterus DungAstragali Radix are the main paired drugs. The paired drugs including Ginseng Radix et RhizomaTrogopterus DungGlycyrrhizae Radixet Rhizoma， Ginseng Radix et RhizomaTrogopterus DungAngelicae Sinensis Radix， Ginseng Radix et RhizomaTrogopterus DungAstragali Radix， Ginseng Radix et RhizomaTrogopterus DungTyphae Pollen have a higher support degree. The main compatible drugs are different in ancient and modern prescriptions including Ginseng Radix et Rhizoma and Trogopterus Dung. Notoginseng Radix et Rhizoma， Typhae Pollen， Salviae Miltiorrhizae Radix et Rhizoma， Astragali Radix are utilized frequently in modern prescriptions while less used in ancient ones. It is also shown that more attentions are paid to the drugs contributing to invigorating Qi and promoting blood circulation in modern times with comparative results between modern and ancient prescriptions., 百拇医药(李梦雯范欣生张泠杉王崇骏)