周细胞与微血管疾病及中医药研究进展(1)
[摘要]周细胞是广泛分布于全身微血管壁的结构细胞，和内皮细胞一起构成微血管和组织间隙的屏障。周细胞通过细胞连接或旁分泌信号与微血管内皮细胞对话，在调控微循环血流量、微血管通透性及血管新生等方面发挥重要作用。多种疾病的微血管病变伴随周细胞结构和功能异常，周细胞的调控成为研究热点。中医学认为微血管病变属于络脉受损，气血瘀滞于络脉导致的脏腑功能异常。中医药干预微血管病变周细胞改变取得了一些进展，如益气活血类中药对于糖尿病视网膜病变微血管周细胞具有较好的改善作用。但是，中医药在微血管病变周细胞研究中也存在着研究领域局限、研究技术和方法不精确及机制阐述深度不足等问题。该文将从周细胞的生物学特征、周细胞与微血管病变及中医药研究进展展开综述，旨为微血管病变周细胞研究及其中医药防治研究提供参考。
[关键词]周细胞；微血管疾病；中医药
Recent advances on pericytes in microvascular dysfunction and
, 百拇医药
traditional Chinese medicine prevention
LI Lei1，2， LIU Jianxun1，2*， GUO Hao1，2， REN Jianxun1，2
(1 Institute of Basic Medical Sciences of Xiyuan Hospital， China Academy of Chinese Medical Sciences， Beijing 100091， China；
2. Beijing Key Laboratory of Chinese Materia Pharmacology， Beijing 100091， China)
[Abstract]Pericytesis a kind of widespread vascular mural cells embedded within the vascular basement membrane of blood microvessels， constituting the barrier of capillaries and tissue spaces together with endothelial cells Pericytes communicate with microvascular endothelial cells through cell connections or paracrine signals， playing an important role in important physiological processes such as blood flow， vascular permeability and vascular formation Pericytes dysfunction may participate in some microvascular dysfunction， and also mediate pathological repair process， therefore pericytes attracted more and more attention Traditional Chinese medicine suggests that microvascular dysfunction belongs to the collaterals disease； Qi stagnation and blood stasis in collaterals result in function imbalance of internal organs Traditional Chinese medicine (TCM) has shown effects on pericytes in microvascular dysfunction， for example qi reinforcing bloodcirculation activating medicines can reduce the damage of retinal pericytes in diabetic retinopathy However， there are some limitations of research fields， inaccuracy of research techniques and methods， and lack of mechanism elaboration depth in the study of microvascular lesion pericytes This paper reviewed the biological characteristics of pericytes and pericytes in microvascular dysfunction， as well as the intervention study of TCM on pericytes The article aims to provide reference for the research of pericytes in microvascular dysfunction and the TCM study on pericytes.
, 百拇医药
[Key words]pericytes； microvascular dysfunction； traditional Chinese medicine
周細胞(pericytes，PCs)又称Rouget细胞或壁细胞，是广泛分布于全身微血管壁的结构细胞，其和内皮细胞一起构成微血管和组织间隙的屏障。近年来，研究显示周细胞与微血管内皮细胞不仅在解剖结构上紧密联系，还能通过细胞连接或旁分泌信号与内皮细胞对话，起到调控微循环血流灌流量及微血管通透性、调节血管新生和创伤愈合、维持微血管紧张度等作用[12]。周细胞功能失调及结构异常和很多微血管性疾病紧密相关，如糖尿病视网膜病变、冠心病、高血压以及肿瘤血管新生等[3]。随着周细胞调控微血管结构和功能研究的深入，周细胞在多种疾病中的作用及其潜在的治疗策略越来越引起研究者的关注[45]。现代中医认为微血管病变属于“络脉”病变的范畴，其主要病变基础为络脉损伤，以气血瘀阻为特征，以脏腑功能障碍为临床表现的一系列病症[67]。近年来，中药在防治微血管病变周细胞改变方面取得了一定进展。该文将从周细胞的生物学特征、周细胞与微血管病变及中医药研究进展进行综述，为微血管病变周细胞研究及其中医药防治研究提供参考。, 百拇医药(李磊刘建勋郭浩任建勋)
[关键词]周细胞；微血管疾病；中医药
Recent advances on pericytes in microvascular dysfunction and
, 百拇医药
traditional Chinese medicine prevention
LI Lei1，2， LIU Jianxun1，2*， GUO Hao1，2， REN Jianxun1，2
(1 Institute of Basic Medical Sciences of Xiyuan Hospital， China Academy of Chinese Medical Sciences， Beijing 100091， China；
2. Beijing Key Laboratory of Chinese Materia Pharmacology， Beijing 100091， China)
[Abstract]Pericytesis a kind of widespread vascular mural cells embedded within the vascular basement membrane of blood microvessels， constituting the barrier of capillaries and tissue spaces together with endothelial cells Pericytes communicate with microvascular endothelial cells through cell connections or paracrine signals， playing an important role in important physiological processes such as blood flow， vascular permeability and vascular formation Pericytes dysfunction may participate in some microvascular dysfunction， and also mediate pathological repair process， therefore pericytes attracted more and more attention Traditional Chinese medicine suggests that microvascular dysfunction belongs to the collaterals disease； Qi stagnation and blood stasis in collaterals result in function imbalance of internal organs Traditional Chinese medicine (TCM) has shown effects on pericytes in microvascular dysfunction， for example qi reinforcing bloodcirculation activating medicines can reduce the damage of retinal pericytes in diabetic retinopathy However， there are some limitations of research fields， inaccuracy of research techniques and methods， and lack of mechanism elaboration depth in the study of microvascular lesion pericytes This paper reviewed the biological characteristics of pericytes and pericytes in microvascular dysfunction， as well as the intervention study of TCM on pericytes The article aims to provide reference for the research of pericytes in microvascular dysfunction and the TCM study on pericytes.
, 百拇医药
[Key words]pericytes； microvascular dysfunction； traditional Chinese medicine
周細胞(pericytes，PCs)又称Rouget细胞或壁细胞，是广泛分布于全身微血管壁的结构细胞，其和内皮细胞一起构成微血管和组织间隙的屏障。近年来，研究显示周细胞与微血管内皮细胞不仅在解剖结构上紧密联系，还能通过细胞连接或旁分泌信号与内皮细胞对话，起到调控微循环血流灌流量及微血管通透性、调节血管新生和创伤愈合、维持微血管紧张度等作用[12]。周细胞功能失调及结构异常和很多微血管性疾病紧密相关，如糖尿病视网膜病变、冠心病、高血压以及肿瘤血管新生等[3]。随着周细胞调控微血管结构和功能研究的深入，周细胞在多种疾病中的作用及其潜在的治疗策略越来越引起研究者的关注[45]。现代中医认为微血管病变属于“络脉”病变的范畴，其主要病变基础为络脉损伤，以气血瘀阻为特征，以脏腑功能障碍为临床表现的一系列病症[67]。近年来，中药在防治微血管病变周细胞改变方面取得了一定进展。该文将从周细胞的生物学特征、周细胞与微血管病变及中医药研究进展进行综述，为微血管病变周细胞研究及其中医药防治研究提供参考。, 百拇医药(李磊刘建勋郭浩任建勋)