中药对Aβ清除作用的研究进展(5)
[39] 邓中甲. 方剂学[M]. 上海：上海科学技术出版社，2008：312.
[40] 程斌，耿东升，谢玲，等.十全大补汤组方中单味药及其复方活性部位的药效学研究[J].解放军药学学报，2006，22(5)：369.
[41] 刘华岩. 十全大补汤对阿尔茨海默病中小胶质细胞作用的实验研究[D].北京：中国医科大学，2008.
Advance in studies on traditional Chinese medicine on Aβ′s scavenging effect
LI Peng1， HUANG Fu-kai3*， YANG Chun1， ZHOU Xin1， LIU Yu-feng1， YAN Bin1， SONG Xiao-ping1， LIU Ya-li2， YUAN Lin1*
(1. Department of Anatomy， Southern Medical University， Guangzhou 510515， China；
2. School of Traditional Chinese Medicine， Southern Medical University， Guangzhou 510515， China；
3.Beijing Tibetan Medical Hospital， Beijing 100029， China)
[Abstract] Aggregation and accumulation of β-amyloid peptide (Aβ) in brain tissues contribute to the pathogenesis of Alzheimer′s disease. Therefore， the promotion of Aβ clearance is one of the key targets for preventing and treatment Alzheimer′s disease. Studies proved that some traditional Chinese medicine(TCM) compounds and extracts could impact the activity of degrading enzyme in amyloid peptide， the transport of hemato encephalic barrier and the phagocytosis of microglial cells， promote Aβ clearance， and improve learning and memory of animal models with Alzheimer′s disease. In this review， we made an summary for the relations between Aβ and Alzheimer′s disease， the Aβ clearance mechanism and the clearance effect of traditional Chinese medicines.
[Key words] traditional Chinese medicine； β-amyloid peptide； clearance
doi：10.4268/cjcmm20132305, http://www.100md.com(李鹏 黄福开 杨春 周辛 刘玉峰 严斌 宋小萍 刘亚丽 原林)
[40] 程斌，耿东升，谢玲，等.十全大补汤组方中单味药及其复方活性部位的药效学研究[J].解放军药学学报，2006，22(5)：369.
[41] 刘华岩. 十全大补汤对阿尔茨海默病中小胶质细胞作用的实验研究[D].北京：中国医科大学，2008.
Advance in studies on traditional Chinese medicine on Aβ′s scavenging effect
LI Peng1， HUANG Fu-kai3*， YANG Chun1， ZHOU Xin1， LIU Yu-feng1， YAN Bin1， SONG Xiao-ping1， LIU Ya-li2， YUAN Lin1*
(1. Department of Anatomy， Southern Medical University， Guangzhou 510515， China；
2. School of Traditional Chinese Medicine， Southern Medical University， Guangzhou 510515， China；
3.Beijing Tibetan Medical Hospital， Beijing 100029， China)
[Abstract] Aggregation and accumulation of β-amyloid peptide (Aβ) in brain tissues contribute to the pathogenesis of Alzheimer′s disease. Therefore， the promotion of Aβ clearance is one of the key targets for preventing and treatment Alzheimer′s disease. Studies proved that some traditional Chinese medicine(TCM) compounds and extracts could impact the activity of degrading enzyme in amyloid peptide， the transport of hemato encephalic barrier and the phagocytosis of microglial cells， promote Aβ clearance， and improve learning and memory of animal models with Alzheimer′s disease. In this review， we made an summary for the relations between Aβ and Alzheimer′s disease， the Aβ clearance mechanism and the clearance effect of traditional Chinese medicines.
[Key words] traditional Chinese medicine； β-amyloid peptide； clearance
doi：10.4268/cjcmm20132305, http://www.100md.com(李鹏 黄福开 杨春 周辛 刘玉峰 严斌 宋小萍 刘亚丽 原林)