In Table 1，compounds 1 and 2 showed promising activity on the BMMSCs proliferation with dose dependent，and the activity is up-regulated with treatment time delay. But the mechanism of this activity need further study.

    Bone marrow mesenchymal stem cells were regarded as the potential for tissue engineering of cartilage because they had the advantage of being easily harvested and power ability of proliferation and multipotent[17]. Developments in therapeutic strategies for cartilage repair have increasingly focused on the promising technology of tissue engineering ......