MicroRNAs作为生物标志物的研究进展(6)
[49] Murata K， Yoshitomi H， Tanida S， et al. Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis [J]. Arthritis Res Ther， 2010， 12(3)： R86.
[50] Wang K， Zhang S L， Marzolf B， et al. Circulating microRNAs， potential biomarkers for druginduced liver injury [J]. Proc Natl Acad Sci USA， 2009， 106(11)： 4402.
[51] Starkey Lewis P J， Dear J， Platt V， et al. Circulating microRNAs as potential markers of human druginduced liver injury [J]. Hepatology， 2011， 54(5)： 1767.
[52] Laterza O F， Lim L， GarrettEngele P W， et al. Plasma micro RNAs as sensitive and specific biomarkers of tissue injury [J]. Clin Chem， 2009， 5(11)： 1977.
Advances of utilizing microRNAs as biomarkers
QIAO Jingyi， JIN Ruomin*
(Research Center for drug Safety Evaluation， Shanghai University of Traditional Chinese Medicine， Shanghai 201203， China)
[Abstract] MicroRNAs (miRNAs) are a new class of endogenous， singlestrand， noncoding small RNAs MiRNAs play an important regulatory role in a variety of pathological and physiological process， such as cell proliferation and apoptosis， organ development and differentiation and tumorigenesis and so on It has been found that circulating miRNAs are also stably and specially expressed in serum or plasma and other body fluids Circulating miRNAs could be taken as noninvasive and new biomarkers for evaluating the druginduced target organ injury， which may play a vital role in monitoring the drug toxicity at the early stage
[Key words] microRNAs； circulating microRNAs； drug toxicity； biomarkers
doi：10.4268/cjcmm20121503
[责任编辑 陈玲], 百拇医药(乔靖怡 金若敏)
[50] Wang K， Zhang S L， Marzolf B， et al. Circulating microRNAs， potential biomarkers for druginduced liver injury [J]. Proc Natl Acad Sci USA， 2009， 106(11)： 4402.
[51] Starkey Lewis P J， Dear J， Platt V， et al. Circulating microRNAs as potential markers of human druginduced liver injury [J]. Hepatology， 2011， 54(5)： 1767.
[52] Laterza O F， Lim L， GarrettEngele P W， et al. Plasma micro RNAs as sensitive and specific biomarkers of tissue injury [J]. Clin Chem， 2009， 5(11)： 1977.
Advances of utilizing microRNAs as biomarkers
QIAO Jingyi， JIN Ruomin*
(Research Center for drug Safety Evaluation， Shanghai University of Traditional Chinese Medicine， Shanghai 201203， China)
[Abstract] MicroRNAs (miRNAs) are a new class of endogenous， singlestrand， noncoding small RNAs MiRNAs play an important regulatory role in a variety of pathological and physiological process， such as cell proliferation and apoptosis， organ development and differentiation and tumorigenesis and so on It has been found that circulating miRNAs are also stably and specially expressed in serum or plasma and other body fluids Circulating miRNAs could be taken as noninvasive and new biomarkers for evaluating the druginduced target organ injury， which may play a vital role in monitoring the drug toxicity at the early stage
[Key words] microRNAs； circulating microRNAs； drug toxicity； biomarkers
doi：10.4268/cjcmm20121503
[责任编辑 陈玲], 百拇医药(乔靖怡 金若敏)