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粪类圆线虫病两例报告(3)
http://www.100md.com 2019年3月1日 《新医学》 20193
     在治疗上,粪类圆线虫病可用伊维菌素0.2 mg/kg每日1次、连用2 d,或阿苯达唑0.4 g每日2次、连用7 d的方案[7]。现有证据表明,伊维菌素的效果优于阿苯达唑,而不良反应轻于阿苯达唑[7]。由于我院无伊维菌素,故仅能使用阿苯达唑治疗。

    综上所述,粪类圆线虫病多发生于免疫功能低下者,临床表现无特异性,可通过粪便、血清学检测及PCR等多种手段诊断,早期诊治有助改善患者预后。

    参 考 文 献

    [1] Jourdan PM, Lamberton PHL, Fenwick A, Addiss DG. Soil-transmitted helminth infections. Lancet,2018,391(10117):252-265.

    [2] Laoraksawong P, Sanpool O, Rodpai R, Thanchomnang T, Kanarkard W, Maleewong W, Kraiklang R, Intapan PM. Current high prevalences of Strongyloides stercoralis and Opisthorchis viverrini infections in rural communities in northeast Thailand and associated risk factors. BMC Public Health,2018,18(1):940.

    [3] Chan FLY, Kennedy B, Nelson R. Fatal Strongyloides hyper-infection syndrome in an immunocompetent adult with review of the literature. Intern Med J,2018,48(7):872-875.

    [4] 李俊达,王晓玲,黄群. 粪类圆线虫二例的临床特征和诊治. 中华传染病杂志,2013,31(5):308-311.

    [5] Requena-Méndez A, Chiodini P, Bisoffi Z, Buonfrate D, Gotuzzo E, Mu?oz J. The laboratory diagnosis and follow up of strongyloidiasis: a systematic review. PLoS Negl Trop Dis,2013,7(1):e2002.

    [6] Nadir E, Grossman T, Ciobotaro P, Attali M, Barkan D, Bardenstein R, Zimhony O. Real-time PCR for Strongyloides stercoralis-associated meningitis. Diagn Microbiol Infect Dis,2016,84(3):197-199.

    [7] Henriquez-Camacho C, Gotuzzo E, Echevarria J, White AC Jr, Terashima A, Samalvides F, Pérez-Molina JA, Plana MN. Ivermectin versus albendazole or thiabendazole for Strongyloides stercoralis infection. Cochrane Database,Syst Rev,2016,18(1):CD007745.

    (收稿日期:2018-10-25)

    (本文編辑:林燕薇), 百拇医药(付锦娴 陈友鹏)
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