【摘要】 各种因素引起的神经元DNA损伤不易修复，持续损伤堆积将诱导突变，从而影响基因组稳定性，损害线粒体功能甚至促进细胞死亡。神经元DNA损伤与多种疾病的病情发展联系紧密，因此神经元DNA的修复一直是神经研究领域的热点。该文对神经元DNA修复机制、相关疾病及促进DNA修复的因素进行了归纳，为将来科研及临床应用提供理论依据及研究方向。

    【关键词】 神经元;DNA修复;退行性疾病;视网膜疾病

    【Abstract】 It is difficult to repair the DNA damage in neurons caused by a variety of factors. The persistent DNA damage will induce mutation， affect genomic instability， destroy mitochondrial function and even accelerate cellular death. DNA damage in neurons is intimately correlated with the progressions of multiple diseases. Consequently ......